Parenteral
Pyelonephritis
Adult: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Recommended dose is expressed as a total of ampicillin/sulbactam combination. Dosage is individualised based on the type or severity of the infection and renal function of the patient. Usual dose range: 1,500-12,000 mg daily in divided doses 6 or 8 hourly via IV inj or IV infusion over 15-30 minutes, or via deep IM inj. Max: 4,000 mg sulbactam daily. In less severe cases, doses may be given 12 hourly. Treatment duration: 5-14 days, may be extended (or additional ampicillin may be given) in severely ill cases.
Child: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Neonate, infant, child 150 mg/kg/day (corresponds to 100 mg ampicillin/50 mg sulbactam/kg/day) in divided doses 6 or 8 hourly via IV inj, IV infusion over 15-30 min, or deep IM inj. Neonate During 1st week of life (particularly preterm): 75 mg/kg/day (50 mg ampicillin/25 mg sulbactam/kg/day) in divided doses 12 hourly. Alternatively, in skin infections: ≥1 year 300 mg/kg/day (200 mg ampicillin/100 mg sulbactam/kg/day) via IV infusion in divided doses 6 hourly for up to 14 days; ≥40 kg: Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to detailed product guideline).
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
≤30 | Less frequent dose administration may be required (refer to detailed product guideline). |
Reconstitution: Initially, reconstitute vial with the appropriate volume of sterile water for inj or any compatible diluent (e.g. 0.5% or 2% lidocaine hydrochloride may also be used for IM inj) to yield a final concentration of 375 mg/mL (250 mg ampicillin/125 mg sulbactam per mL). For IV infusion: Further dilute the reconstituted solution with a compatible diluent. Refer to specific product guidelines for further information on reconstitution.
Incompatibility: Incompatible with blood products or protein hydrolysates; aminoglycosides (avoid mixing in the same container or concurrent Y-site administration; reconstitute and administer separately).
Parenteral
Upper and lower respiratory tract infections
Adult: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Recommended dose is expressed as a total of ampicillin/sulbactam combination. Dosage is individualised based on the type or severity of the infection and renal function of the patient. Usual dose range: 1,500-12,000 mg daily in divided doses 6 or 8 hourly via IV inj or IV infusion over 15-30 minutes, or via deep IM inj. Max: 4,000 mg sulbactam daily. In less severe cases, doses may be given 12 hourly. Treatment duration: 5-14 days, may be extended (or additional ampicillin may be given) in severely ill cases.
Child: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Neonate, infant, child 150 mg/kg/day (corresponds to 100 mg ampicillin/50 mg sulbactam/kg/day) in divided doses 6 or 8 hourly via IV inj, IV infusion over 15-30 min, or deep IM inj. Neonate During 1st week of life (particularly preterm): 75 mg/kg/day (50 mg ampicillin/25 mg sulbactam/kg/day) in divided doses 12 hourly. Alternatively, in skin infections: ≥1 year 300 mg/kg/day (200 mg ampicillin/100 mg sulbactam/kg/day) via IV infusion in divided doses 6 hourly for up to 14 days; ≥40 kg: Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to detailed product guideline).
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
≤30 | Less frequent dose administration may be required (refer to detailed product guideline). |
Reconstitution: Initially, reconstitute vial with the appropriate volume of sterile water for inj or any compatible diluent (e.g. 0.5% or 2% lidocaine hydrochloride may also be used for IM inj) to yield a final concentration of 375 mg/mL (250 mg ampicillin/125 mg sulbactam per mL). For IV infusion: Further dilute the reconstituted solution with a compatible diluent. Refer to specific product guidelines for further information on reconstitution.
Incompatibility: Incompatible with blood products or protein hydrolysates; aminoglycosides (avoid mixing in the same container or concurrent Y-site administration; reconstitute and administer separately).
Parenteral
Intra-abdominal infections
Adult: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Recommended dose is expressed as a total of ampicillin/sulbactam combination. Dosage is individualised based on the type or severity of the infection and renal function of the patient. Usual dose range: 1,500-12,000 mg daily in divided doses 6 or 8 hourly via IV inj or IV infusion over 15-30 minutes, or via deep IM inj. Max: 4,000 mg sulbactam daily. In less severe cases, doses may be given 12 hourly. Treatment duration: 5-14 days, may be extended (or additional ampicillin may be given) in severely ill cases.
Child: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Neonate, infant, child 150 mg/kg/day (corresponds to 100 mg ampicillin/50 mg sulbactam/kg/day) in divided doses 6 or 8 hourly via IV inj, IV infusion over 15-30 min, or deep IM inj. Neonate During 1st week of life (particularly preterm): 75 mg/kg/day (50 mg ampicillin/25 mg sulbactam/kg/day) in divided doses 12 hourly. Alternatively, in skin infections: ≥1 year 300 mg/kg/day (200 mg ampicillin/100 mg sulbactam/kg/day) via IV infusion in divided doses 6 hourly for up to 14 days; ≥40 kg: Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to detailed product guideline).
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
≤30 | Less frequent dose administration may be required (refer to detailed product guideline). |
Reconstitution: Initially, reconstitute vial with the appropriate volume of sterile water for inj or any compatible diluent (e.g. 0.5% or 2% lidocaine hydrochloride may also be used for IM inj) to yield a final concentration of 375 mg/mL (250 mg ampicillin/125 mg sulbactam per mL). For IV infusion: Further dilute the reconstituted solution with a compatible diluent. Refer to specific product guidelines for further information on reconstitution.
Incompatibility: Incompatible with blood products or protein hydrolysates; aminoglycosides (avoid mixing in the same container or concurrent Y-site administration; reconstitute and administer separately).
Parenteral
Gynaecological infections
Adult: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Recommended dose is expressed as a total of ampicillin/sulbactam combination. Dosage is individualised based on the type or severity of the infection and renal function of the patient. Usual dose range: 1,500-12,000 mg daily in divided doses 6 or 8 hourly via IV inj or IV infusion over 15-30 minutes, or via deep IM inj. Max: 4,000 mg sulbactam daily. In less severe cases, doses may be given 12 hourly. Treatment duration: 5-14 days, may be extended (or additional ampicillin may be given) in severely ill cases.
Child: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Neonate, infant, child 150 mg/kg/day (corresponds to 100 mg ampicillin/50 mg sulbactam/kg/day) in divided doses 6 or 8 hourly via IV inj, IV infusion over 15-30 min, or deep IM inj. Neonate During 1st week of life (particularly preterm): 75 mg/kg/day (50 mg ampicillin/25 mg sulbactam/kg/day) in divided doses 12 hourly. Alternatively, in skin infections: ≥1 year 300 mg/kg/day (200 mg ampicillin/100 mg sulbactam/kg/day) via IV infusion in divided doses 6 hourly for up to 14 days; ≥40 kg: Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to detailed product guideline).
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
≤30 | Less frequent dose administration may be required (refer to detailed product guideline). |
Reconstitution: Initially, reconstitute vial with the appropriate volume of sterile water for inj or any compatible diluent (e.g. 0.5% or 2% lidocaine hydrochloride may also be used for IM inj) to yield a final concentration of 375 mg/mL (250 mg ampicillin/125 mg sulbactam per mL). For IV infusion: Further dilute the reconstituted solution with a compatible diluent. Refer to specific product guidelines for further information on reconstitution.
Incompatibility: Incompatible with blood products or protein hydrolysates; aminoglycosides (avoid mixing in the same container or concurrent Y-site administration; reconstitute and administer separately).
Parenteral
Bone and joint infections
Adult: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Recommended dose is expressed as a total of ampicillin/sulbactam combination. Dosage is individualised based on the type or severity of the infection and renal function of the patient. Usual dose range: 1,500-12,000 mg daily in divided doses 6 or 8 hourly via IV inj or IV infusion over 15-30 minutes, or via deep IM inj. Max: 4,000 mg sulbactam daily. In less severe cases, doses may be given 12 hourly. Treatment duration: 5-14 days, may be extended (or additional ampicillin may be given) in severely ill cases.
Child: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Neonate, infant, child 150 mg/kg/day (corresponds to 100 mg ampicillin/50 mg sulbactam/kg/day) in divided doses 6 or 8 hourly via IV inj, IV infusion over 15-30 min, or deep IM inj. Neonate During 1st week of life (particularly preterm): 75 mg/kg/day (50 mg ampicillin/25 mg sulbactam/kg/day) in divided doses 12 hourly. Alternatively, in skin infections: ≥1 year 300 mg/kg/day (200 mg ampicillin/100 mg sulbactam/kg/day) via IV infusion in divided doses 6 hourly for up to 14 days; ≥40 kg: Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to detailed product guideline).
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
≤30 | Less frequent dose administration may be required (refer to detailed product guideline). |
Reconstitution: Initially, reconstitute vial with the appropriate volume of sterile water for inj or any compatible diluent (e.g. 0.5% or 2% lidocaine hydrochloride may also be used for IM inj) to yield a final concentration of 375 mg/mL (250 mg ampicillin/125 mg sulbactam per mL). For IV infusion: Further dilute the reconstituted solution with a compatible diluent. Refer to specific product guidelines for further information on reconstitution.
Incompatibility: Incompatible with blood products or protein hydrolysates; aminoglycosides (avoid mixing in the same container or concurrent Y-site administration; reconstitute and administer separately).
Parenteral
Bacterial septicaemia
Adult: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Recommended dose is expressed as a total of ampicillin/sulbactam combination. Dosage is individualised based on the type or severity of the infection and renal function of the patient. Usual dose range: 1,500-12,000 mg daily in divided doses 6 or 8 hourly via IV inj or IV infusion over 15-30 minutes, or via deep IM inj. Max: 4,000 mg sulbactam daily. In less severe cases, doses may be given 12 hourly. Treatment duration: 5-14 days, may be extended (or additional ampicillin may be given) in severely ill cases.
Child: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Neonate, infant, child 150 mg/kg/day (corresponds to 100 mg ampicillin/50 mg sulbactam/kg/day) in divided doses 6 or 8 hourly via IV inj, IV infusion over 15-30 min, or deep IM inj. Neonate During 1st week of life (particularly preterm): 75 mg/kg/day (50 mg ampicillin/25 mg sulbactam/kg/day) in divided doses 12 hourly. Alternatively, in skin infections: ≥1 year 300 mg/kg/day (200 mg ampicillin/100 mg sulbactam/kg/day) via IV infusion in divided doses 6 hourly for up to 14 days; ≥40 kg: Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to detailed product guideline).
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
≤30 | Less frequent dose administration may be required (refer to detailed product guideline). |
Reconstitution: Initially, reconstitute vial with the appropriate volume of sterile water for inj or any compatible diluent (e.g. 0.5% or 2% lidocaine hydrochloride may also be used for IM inj) to yield a final concentration of 375 mg/mL (250 mg ampicillin/125 mg sulbactam per mL). For IV infusion: Further dilute the reconstituted solution with a compatible diluent. Refer to specific product guidelines for further information on reconstitution.
Incompatibility: Incompatible with blood products or protein hydrolysates; aminoglycosides (avoid mixing in the same container or concurrent Y-site administration; reconstitute and administer separately).
Parenteral
Skin and skin structure infections
Adult: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Recommended dose is expressed as a total of ampicillin/sulbactam combination. Dosage is individualised based on the type or severity of the infection and renal function of the patient. Usual dose range: 1,500-12,000 mg daily in divided doses 6 or 8 hourly via IV inj or IV infusion over 15-30 minutes, or via deep IM inj. Max: 4,000 mg sulbactam daily. In less severe cases, doses may be given 12 hourly. Treatment duration: 5-14 days, may be extended (or additional ampicillin may be given) in severely ill cases.
Child: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Neonate, infant, child 150 mg/kg/day (corresponds to 100 mg ampicillin/50 mg sulbactam/kg/day) in divided doses 6 or 8 hourly via IV inj, IV infusion over 15-30 min, or deep IM inj. Neonate During 1st week of life (particularly preterm): 75 mg/kg/day (50 mg ampicillin/25 mg sulbactam/kg/day) in divided doses 12 hourly. Alternatively, in skin infections: ≥1 year 300 mg/kg/day (200 mg ampicillin/100 mg sulbactam/kg/day) via IV infusion in divided doses 6 hourly for up to 14 days; ≥40 kg: Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to detailed product guideline).
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
≤30 | Less frequent dose administration may be required (refer to detailed product guideline). |
Reconstitution: Initially, reconstitute vial with the appropriate volume of sterile water for inj or any compatible diluent (e.g. 0.5% or 2% lidocaine hydrochloride may also be used for IM inj) to yield a final concentration of 375 mg/mL (250 mg ampicillin/125 mg sulbactam per mL). For IV infusion: Further dilute the reconstituted solution with a compatible diluent. Refer to specific product guidelines for further information on reconstitution.
Incompatibility: Incompatible with blood products or protein hydrolysates; aminoglycosides (avoid mixing in the same container or concurrent Y-site administration; reconstitute and administer separately).
Parenteral
Urinary tract infections
Adult: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Recommended dose is expressed as a total of ampicillin/sulbactam combination. Dosage is individualised based on the type or severity of the infection and renal function of the patient. Usual dose range: 1,500-12,000 mg daily in divided doses 6 or 8 hourly via IV inj or IV infusion over 15-30 minutes, or via deep IM inj. Max: 4,000 mg sulbactam daily. In less severe cases, doses may be given 12 hourly. Treatment duration: 5-14 days, may be extended (or additional ampicillin may be given) in severely ill cases.
Child: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Neonate, infant, child 150 mg/kg/day (corresponds to 100 mg ampicillin/50 mg sulbactam/kg/day) in divided doses 6 or 8 hourly via IV inj, IV infusion over 15-30 min, or deep IM inj. Neonate During 1st week of life (particularly preterm): 75 mg/kg/day (50 mg ampicillin/25 mg sulbactam/kg/day) in divided doses 12 hourly. Alternatively, in skin infections: ≥1 year 300 mg/kg/day (200 mg ampicillin/100 mg sulbactam/kg/day) via IV infusion in divided doses 6 hourly for up to 14 days; ≥40 kg: Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to detailed product guideline).
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
≤30 | Less frequent dose administration may be required (refer to detailed product guideline). |
Reconstitution: Initially, reconstitute vial with the appropriate volume of sterile water for inj or any compatible diluent (e.g. 0.5% or 2% lidocaine hydrochloride may also be used for IM inj) to yield a final concentration of 375 mg/mL (250 mg ampicillin/125 mg sulbactam per mL). For IV infusion: Further dilute the reconstituted solution with a compatible diluent. Refer to specific product guidelines for further information on reconstitution.
Incompatibility: Incompatible with blood products or protein hydrolysates; aminoglycosides (avoid mixing in the same container or concurrent Y-site administration; reconstitute and administer separately).
Parenteral
Prophylaxis of surgical infections
Adult: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Recommended dose is expressed as a total of ampicillin/sulbactam combination. In patients undergoing pelvic or abdominal surgery in which peritoneal contamination may be present, or in termination of pregnancy or caesarean section: 1,500-3,000 mg via IV or IM at induction of anaesthesia, may be repeated 6-8 hourly. Administration may be discontinued 24 hours after the majority of surgical procedures, unless therapeutic use is clinically indicated.
Renal impairment:
CrCl (ml/min) | Dosage Recommendation |
≤30 | Less frequent dose administration may be required (refer to detailed product guideline). |
Reconstitution: Initially, reconstitute vial with the appropriate volume of sterile water for inj or any compatible diluent (e.g. 0.5% or 2% lidocaine hydrochloride may also be used for IM inj) to yield a final concentration of 375 mg/mL (250 mg ampicillin/125 mg sulbactam per mL). For IV infusion: Further dilute the reconstituted solution with a compatible diluent. Refer to specific product guidelines for further information on reconstitution.
Incompatibility: Incompatible with blood products or protein hydrolysates; aminoglycosides (avoid mixing in the same container or concurrent Y-site administration; reconstitute and administer separately).
Parenteral
Uncomplicated gonorrhoea
Adult: Available preparations: Ampicillin 250 mg and sulbactam 125 mg powder for solution for inj or infusion Ampicillin 500 mg and sulbactam 250 mg powder for solution for inj or infusion Ampicillin 1,000 mg and sulbactam 500 mg powder for solution for inj or infusion Ampicillin 2,000 mg and sulbactam 1,000 mg powder for solution for inj or infusion Recommended dose is expressed as a total of ampicillin/sulbactam combination. In combination with oral probenecid: 1,500 mg as single dose via IV or IM.
Reconstitution: Initially, reconstitute vial with the appropriate volume of sterile water for inj or any compatible diluent (e.g. 0.5% or 2% lidocaine hydrochloride may also be used for IM inj) to yield a final concentration of 375 mg/mL (250 mg ampicillin/125 mg sulbactam per mL). For IV infusion: Further dilute the reconstituted solution with a compatible diluent. Refer to specific product guidelines for further information on reconstitution.
Incompatibility: Incompatible with blood products or protein hydrolysates; aminoglycosides (avoid mixing in the same container or concurrent Y-site administration; reconstitute and administer separately).